POS0568 OBESITY RATES AND BMI ARE SIMILAR IN AGE AND SEX MATCHED RHEUMATOID ARTHRITIS, PSORIATIC ARTHRITIS AND SPONDYLOARTHRITIS PATIENTS

Background: Obesity has been suggested to be a chronic inflamatory condition and therefore, obesity may considered as risk factor for developing immune-mediated diseases, including inflammatory arthritis. In larger biologic registiries, was found frequently in psoriatic arthritis than other diseases such rheumatoid spondyloarthritis. [1-4]. However, reason of aging, moreover, there are strong sex differences between those diseases. Objectives: The aim this study evaluate the rates aged matched patients with before initation biological therapy. Methods: HUR-BIO (Hacettepe University Biologic Registry) is prospective, single center database treatments since 2005 date 5635 have recorded. Demographic, clinical laboratory data bDMARD SpA, RA PsA were noted. divided into two groups: non-obese (<30 kg/ m 2 ) obese (≥30 kg/m patients. When investigeting changes BMI by diagnosis, effects gender age adjusted using two-way ANOVA ANCOVA tests. selection made indifferences relevant groups propensity score. Results: 5059 patients’ (1834 RA, 2741 SpA 484 PsA) avaliable analysed. Baseline characteristics given Table 1. 72.3% seropositive. HLAB27 positive 64.7% 22.9% Anti-TNF therapy started first 57.2% patients, others non-Anti-TNF bDMARDs. (99.2%) (100%) anti-TNFs biologics. Overall, proportion significantly higher (Table 1) affected (p<0.001) (Figure 1). After adjusting indifference groups, difference disappeared p All N 1834 Female, n (% 1470 (80.2) 1257 (45.9) 334 (69.0) 0.000* Age, years* 52.9±13.4 43.1±11.4 47.4±12.2 Disease duration, years ¥ 11 (7-17) 8 (5-13) 7 (3-12) Body mass index* 29.6 ± 6.5 27.7 5.4 29.2 5.8 Obesity, 811 (44.2) 815 (29.7) 199 (41.1) Age group 481 483 315 (65.7) 324 (67.1) 0.545 47 (36-59) 48 (39-57) (38-56) 0.691 10 (6-15) 5 28.5 6.1 0.150 183 (38.0) 176 (36.4) 0.316 * Mean ±S.D Median (IQR) Conclusion: Although more reported seemed major factors occurrence rather subgroups. Therefore, when considering registries, instance should kept mind. References: [1]Højgaard, P., et al., influence on response tumour necrosis factor-α inhibitors arthritis: results from DANBIO ICEBIO registries. Rheumatology (Oxford), 2016. 55 (12): p. 2191-2199. [2]Liu, Y., Impact Remission Activity Rheumatoid Arthritis: A Systematic Review Meta-Analysis. Arthritis Care Res (Hoboken), 2017. 69 (2): 157-165. [3]Moroni, L., N. Farina, L. Dagna, its role management Clin Rheumatol, 2020. 39 (4): 1039-1047. [4]Zurita Prada, P.A., Influence smoking treatment axial spondyloarthritis: systematic literature review. Figure regarding subtypes Disclosure Interests: None declared